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Metabolites linked to physical wellness

It is well known that performing regular aerobic exercises—like running—lead to strong cardiovascular performance, slim figure, break down of fat and sugar, and good blood sugar control. However, it is not clearly understood why these metabolic changes happen.

Unlike the well-studied human genome, scientists have just recently started to learn the intricate language of metabolites in the human body. These chemicals may prove valuable in elucidating the benefits from exercise.

In a large scale study, researchers observed that two metabolites—glycerol and glutamine—were elevated in 302 participants after running the marathon. The chemicals also varied with resting heart rate, which may indicate physical well-being. In another study, 21 metabolites—plus others that were not previously related to exercise—were detected among 70 individuals after a ten-minute run. Some metabolites were highly elevated after extreme physical exertion, which may be linked to endurance.

Scientists are puzzled as to the why these changes occur. As of the moment, what is known is that metabolites are increased after work-outs. Further animal and in vitro studies are needed to level up what we know. Metabolic profiling, in addition to genetics and protein studies, may just provide the answers.

This information is intended for educational and informational purposes only. It should not be used in place of an individual consultation or examination or replace the advice of your health care professional and should not be relied upon to determine diagnosis or course of treatment.

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Welcome to our UpToDate library. The information shared below is provided to you as an educational and informational source only and is not intended to replace a medical examination or consultation, or medical advice given to you by a physician or medical professional.

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